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While opioids activate brain chemistry related to pleasure and dependence by binding to mu-opioid receptors, acetaminophen primarily reduces pain by blocking cyclooxygenase (COX) enzymes in the brain and spinal cord

Cell culture and characterization The human BBB co-culture model based on stem cell-derived endothelial cells (hEC) and brain pericytes (PC) were established and characterized by the group of Ceccelli et al

Astrocyte reactivity and inflammation-induced depression-like behaviors are regulated by Orai1 calcium channels

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