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Manipulating ferritin levels through ferritinophagy can influence the iron abundance and the susceptibility to ferroptosis (50, 51)

However, the overall safety database by modern standards is still limited

However, other PDZ-binding proteins are known to also regulate CFTR localization and function, including NHERF2 55,84 , CAL (CFTR-associated ligand) 85 , and CAP70 (CFTR associated protein) 86 Furthermore, other non-PDZ-dependent mechanisms may contribute, since the physiologic dimers of CFTR are assembled independently of either NHERF1 or NHERF2, thus leaving PDZ-domains available for other interactions 55

The strongest evidence layer in this stack

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However, AHA causes numerous severe side effects including teratogenesis and haemolytic anaemia, which have reduced its clinical use (Williams et al., 1984