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Since changes in bone tissue manifest as fractures with a long delay, this may hint at more pronounced slow-acting effects on bone of the two drugs, although imbalances in confounding factors between the groups may also arise as time passes

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In contrast, the delayed phase involves transcriptional upregulation and synthesis of cytoprotective proteins, such as superoxide dismutase, heat shock proteins, and inducible nitric oxide synthase, along with modulation of anti-apoptotic pathways

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