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JAMA 327 , 534545 (2022)

What are the side effects of GLP-1 patches

The phase 2 trial data explicitly shows this is a bad idea

cAMP activates PKA and Epac-2 signal transduction pathways, PKA and Epac-2 lead to the closure of ATP-sensitive potassium channels, which in turn causes depolarization of the cell membrane and opening of voltage-dependent calcium channels, resulting in uptake of calcium and stimulation of the exocytosis of insulin granules and blood glucose control of T2DM patients

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doi: 10.1055/s-2004-826175 141 MeierJJGallwitzBSalmenSGoetzeOHolstJJSchmidtWEet al