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It has even recently been suggested that cortical electroencephalogram arousal patterns are not sufficiently sensitive to detect arousals from sleep in children, and that outputs of the autonomic nervous system may be a better alternative for this purpose (29)

10.1016/s1474-4422(21)00252-0 Lancet Neurol

Initial investigations into the causes of adult onset GHD showed them to result from damage to the pituitary gland due to tumors, surgery or radiotherapy that disrupted function of the GH neuroendocrine axis

Due to its large molecule size, it doesn't penetrate beyond the skin's surface

Gabibov and A

These individuals are usually completely dependent on others for care, require tube feeding, are unable to complete personal hygiene, and are highly sensitive to sensory stimuli (40)