Future trials should also measure important outcomes such as the clinical signs and symptoms of vitamin B 12 deficiency, health related-quality of life, socioeconomic effects, and report adverse events adequately, preferably in a primary care setting. Clinical practice guidelines British Columbia Medical Services Commission (MSC)
References Vaz C, Silva G, Carvalho T, Serra C, Brs L, Fonseca L, et al
with different cytotoxicities (Utami et al., 2018)
Following 6 months of treatment with 400 mg every 2 weeks, the dose was reduced to 200 mg every 2 weeks for maintenance and continued for up to 5 years
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