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Retatrutide adds glucagon receptor activation on top of GLP-1 and GIP, producing a triple mechanism

Elashoff M, Matveyenko AV, Gier B, Elashoff R, Butler PC

The multifaceted potential of glucagon-like peptide-1 as a therapeutic agent

More data show GLP-1s may reduce addiction risk

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[11] Structure [edit] The GLP-1 receptor is a transmembrane protein composed of seven alpha-helical transmembrane domains (TM1-TM7), an extracellular N-terminus, and an intracellular C-terminus