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Polyunsaturated fats are found in nuts and plant oils, while monounsaturated fats are found in olive, canola, soy, and sunflower oils and avocados (Field and Robinson 2019)

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The gut microbiota dysbiosis promoted BA homeostasis disbalance, characterized by the accumulation of LCA and DCA in feces ( The alteration of BAs may also regulate the intestinal immune response ( via the smooth muscle cells present in the atheromatosus vessels of patients suffering from obesity-related NAFLD ( In conclusion, the current study demonstrates that HZRG treatment counteracts MCD-induced liver steatosis and inflammation, the beneficial effects of HZRG are associated with the modulation of gut dysbiosis and promotion of fecal BA excretion (Figure 7)

These observations suggest that GPX4 and FTH1 are upregulated in patients undergoing neoadjuvant chemoradiotherapy, and high levels of both are associated with recurrence and poor prognosis in colorectal cancer

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