The gut-brain axis is a well-documented physiological system, and stress-related GI symptoms are clinically recognized
Advocates of microdosing GLP-1 suggest several potential advantages, primarily centred on reducing the gastrointestinal side effects commonly associated with standard doses
Diabetes 65 , 14871489 (2016)
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In our systematic review and meta-analysis evaluating the clinical efficacy and safety of combinations of DPP-4 inhibitors and SGLT2 inhibitors in patients with inadequately controlled type 2 diabetes, the combination of an SGLT2 inhibitor and a DPP-4 inhibitor showed a greater reduction in HbA1c (weighted mean difference, 0.6%), fasting plasma glucose, and 2-hour postprandial plasma glucose levels than the combination of a placebo with a DPP-4 inhibitor [47]
An oral version of semaglutide already exists
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