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By integrating primary hepatocytes with non-parenchymal liver cells under continuous perfusion, the human liver-on-chip maintained long-term metabolic competence and reproduced clinically relevant mechanisms of drug-induced liver injury (DILI) at exposure levels comparable to patient plasma concentrations

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[DOI] [PMC free article] [PubMed] [Google Scholar] 61.Harris R.C., Foster C.V., Hultman E

But what comes nextthe simple act of adding liquidis arguably one of the most critical and overlooked steps in the entire research process