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27-34 Of note, several trials in the PIONEER program used two estimands to further distinguish their analyses: 1) a treatment-policy estimand, which used data collected at the end of the study period (e.g., week 26 or 52) in the analysis regardless of treatment discontinuation or use of rescue medication
The active ingredient in Zepbound, tirzepatide, is a dual receptor agonist
semaglutide: clinical decision-making in the GLP-1 landscape Tirzepatide Versus Semaglutide on Weight Loss in Type 2 Diabetes Patients: A Systematic Review and Meta-Analysis of Direct Comparative Studies Tirzepatide: A Systematic Update Efficacy and safety of tirzepatide, dual GLP-1/GIP receptor agonists, in the management of type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials Tirzepatide, a dual GIP/GLP-1 receptor agonist, alleviates metabolic dysfunction-associated steatotic liver disease by reducing the expression of CD36 and OBP2A
Ryan said that "we do need better evidence" around whether some individuals can maintain weight loss after coming off GLP-1s, but she thinks what "Calibrate is doing is sharing the decision-making with the patient and trying to adapt to the environment where drugs may not always be available." Since Calibrate has come onto the market, results were published from a much larger, peer-reviewed study funded by the Ozempic manufacturer Novo Nordisk in 2022
