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In clinical trials, Tesamorelin did not significantly worsen overall glucose tolerance

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Indeed, there may be synergy between FGF-21 and GCG receptor agonism, due to their similar metabolic actions, particularly related to brown adipose tissue differentiation and activation [32], with FGF21 having additional actions in the liver, reducing hepatic lipogenesis and enhancing hepatic insulin sensitivity [66, 67]

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DMH, dorsomedial nucleus of the hypothalamus

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