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Lumbar spine BMD tended to decrease in the LC group after the 3-month intervention (p = 0.069), but no other changes in BMD were noted (Table 3)

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The resulting cytoplasmic fraction was supplemented with protease inhibitors, stored at 80 C, and later used in assays for apoptotic cell death and Western blotting

While the beneficial effects of low IGF-1 action on aging seems well supported by data in model systems 6,7 and unique human populations 13,16 , a broader examination of the literature suggests that a more nuanced, complex, and controversial relationship exists between IGF-1, aging, and disease, which is indicative of the pleiotropic actions attributed to IGF-1 in cells and tissues 12,19

46 A similarly designed study that tested 90 days of supplementation with B

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