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GLP-1s slow down digestion, so big meals can sit heavy in the stomach and trigger nausea

If a patient develops symptoms such as burning stomach pain, black stools, vomiting blood, or severe nausea , they should immediately consult their healthcare provider and consider stopping semaglutide if recommended

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According to the Rybelsus SmPC (available on the Electronic Medicines Compendium) and the EMA's European Public Assessment Report (EPAR), oral semaglutide uses a proprietary absorption enhancer called SNAC (sodium N-[8-(2-hydroxybenzoyl) aminocaprylate]) to facilitate absorption through the gastric mucosa

(2011) found that cytokine signaling inhibitory factor 1 (SOCS1) regulates hepatocyte proliferation through the HGF/c-Met axis

BMJ Open 2024;14:e083550