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FOXO4-DRI: Senolytic Peptide Mechanism and the p53-FOXO4 Axis FOXO4-DRI is a D-retro-inverso peptide that selectively kills senescent cells by disrupting the protective FOXO4-p53 interaction

Summary: This phase 2 trial, a precursor to the phase 3 studies, provided the initial evidence for the superior efficacy of the CagriSema combination

Consider sleep position optimization for spinal alignment

Daily dosing is reserved for acute immune challenges or practitioner-guided protocols

Self-administered intra-articular injection risks septic arthritis (joint infection), which requires emergency IV antibiotics and possible surgical drainage within 24-48 hours of onset

Any weight change tracks the programme, over weeks to months