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It is generally recommended to start with a lower dose and "titrate" or slowly increase the amount over a week or two to allow your system to adapt

PubMed Chantachaeng W, Chularojanamontri L, Kulthanan K, Jongarearnprasert K, Dhana N

There is a reference to potential metabolic consequences, which may relate to the bodys regulation of energy and tissue equilibrium [4][5]

Persistent hyperglycemia can mediate hypoxic or ischemic injury, as well as elicit cardiomyocyte contractile dysfunction and the NF-B signaling pathway activation, thus inducing ER stress [152]

Wang, N., Wu, R., Tang, D