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Amino acid metabolism and pulmonary fibrosis Arginine plays a key role in pulmonary fibrosis Arginineproline metabolism in pulmonary fibrosis Emerging evidence indicates that the arginineproline metabolic axis is notably upregulated in pulmonary fibrosis, contributing to excessive ECM deposition and disease progression [66,67,68,69,70]

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This means they slot naturally into human physiology, which explains both their therapeutic potential and why pharmaceutical companies invest billions developing synthetic versions