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In severe cases of dehydration, the body conserves water by reducing urine production, leading to infrequent or dark-colored urine

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The lack of ATP collapses the vesicular proton gradient, forcing stored catecholamines to leak out of the vesicles and flood the axoplasm/cytoplasm of the nerve terminal (Silver et al., 2001)

The primary endpoint was the percent change in weight from baseline at 72 weeks