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Obesity and Body Composition Weight gain is a common concern in hypothyroid patients, especially in Hashimotos disease, where autoimmune activity may coexist with metabolic dysfunction

A study published in September 2025 in JAMA Surgery ( Journal of the American Medical Association )1 involved more than 30,458 patients who were tracked for two years

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It will remain to be seen to what extent a GLP-1 pill can maintain these results, as earlier clinical trials have shown it required ~280x the dose of semaglutide in a pill than in an injection to see the same effects

TeSlaa T, Ralser M, Fan J, Rabinowitz JD

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