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10.1179/1607845415Y.0000000046 81

10.3389/fcvm.2023.1129349 157

Collectively, our data reveal that Y37P substitution in Cagri (from Amy) promotes differential engagement of the Cagri peptide with each RAMP that contributes to distinct conformational dynamics from those observed for each individual rAmy-bound AMYR complex

At 30 min after isoprenaline 75 mg/kg s.c., we noted an early multiorgan failure (brain, heart, lung, liver, kidney and gastrointestinal lesions), thrombosis, intracranial (superior sagittal sinus) hypertension, portal and caval hypertension, and aortal hypotension, full presentation (or attenuation by BPC 157 therapy (given at 5 min after isoprenaline) via activation of the azygos vein) (Figure 1, Figure 2, Figure 3, Figure 4, Figure 5, Figure 6, Figure 7, Figure 8 and Figure 9)