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As 2025 ended, the Trump administration announced that it would seek to lower costs and increase access to GLP-1s for Medicare and Medicaid recipients

In TRIUMPH-4, the 12mg group had higher rates of dysesthesia (20.9% vs

Last reviewed: June 6, 2026 Last updated: June 6, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Semaglutide targets one receptor (GLP-1), while tirzepatide targets two (GIP + GLP-1)

transdermal systems may additionally cause local skin reactions