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This article summarizes that literature in chronological and thematic order, attributing each finding to its original authors and study design

Produced on equipment that processes dairy, soy, peanuts, and tree nuts individuals with severe allergies should consult their physician

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Severe or prolonged vomiting with signs of dehydration such as dizziness, reduced urine output, or extreme thirst which may indicate a risk of acute kidney injury

In both patient populations with pre-existing cardiovascular disease, DPP-4 inhibitors are recommended as one possible third-line therapy besides SGLT-2 inhibitors, thiazolidinediones, or insulin, when therapeutic goals are not met with the previous dual combination

Hypoglycemia: While Semaglutides risk of hypoglycemia is lower when used alone (not with insulin or sulfonylureas), its blood sugar-lowering effects combined with the metabolic changes induced by Topiramate and significant weight loss necessitate vigilant blood sugar monitoring, especially in individuals with diabetes