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Made in the liver, Its main mechanism of detoxification is through an enzyme called glutathione S-transferase (GST)

Importantly, induction of the proteasome is required for adaptation to oxidative stress [91] and can extend the life span of human fibroblasts [92]

However, TMAO inhibited the activity of pyruvate dehydrogenase (PDH) and weakened the oxidation of pyruvate in mitochondria, which impaired production of ATP (101)

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Although it is a slightly lower dose, it will probably do the job