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At the level of thyroid hormone synthesis, TNF- can directly inhibit the activity of thyroid peroxidase (TPO), and IL-1 stimulates iodothyronine 5-deiodine activity in the liver to affect the metabolism of thyroid hormone (Fujii et al., 1989)

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Lactate acts as a redox buffer by modulating the NAD(P)H/NAD(P)+ ratio and serves as a signaling molecule that regulates the activity of antioxidant enzymes involved in ROS metabolism