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We compared the prevalence of NCHPTH in our MBDS to other referral populations, finding an increased prevalence in our service, likely due to the high frequency of skeletal compromise in this population

According to previous studies on the relaxation time of deuterated compounds [23, 32], the T 1 values of HDO and [6,6]- 2 H 2 glucose were set as 320 and 64 ms, respectively, during analysis

Moreover, despite more semaglutide-treated patients starting at doses higher than the minimal dose and reaching the higher approved maintenance doses (i.e., 10 mg for tirzepatide and 1.7 mg for semaglutide) during follow-up, weight reduction remained greater in the tirzepatide group

However, the absence of fibre may lead to changes in gut microbiome composition, which could have long-term consequences

86,87 The lysine methyl transferase KMT DOT1L demethylates histone H3 at lysine 79 (H3K79me2) which promotes lineage-specific gene expression to regulate T H cell function

kDa, kilo Dalton