Two factors compound: drug exposure scales with body weight (lighter body = more drug per pound), and physiological response varies by metabolic and cardiovascular phenotype
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Five more peptides are scheduled for a later PCAC meeting before the end of February 2027
To maintain their lead, Novo and Eli Lilly are also working on next-generation treatments, targeting some of the same gaps in the marketplace
The chronic nature of obesity means that medication cessation often leads to rapid weight regain
Conflict of interest JR-F declares that he has received honoraria for lectures for AstraZeneca, Boehringer Ingelheim, Novo Nordisk, Lilly, Sanofi, Novartis, Abbvie, Merck, and Bayer