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Journal of Signal Transduction 2012, 2012 , 1-13

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Drug Targets 21 , 785800 (2021)

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Notably, non-internalized NPs like pristine SiO 2 NPs [452] and LaVO 4 :Eu 3+ NPs [459] can still trigger eryptosis, relying on Ca 2+ signaling, which can be mediated by their direct influence on Piezo1 channels

Dose selection therefore depends on the outcome and the tolerability cost of reaching it