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However, the inhibition of -GCS activity by GSH is of physiological significance [7] and is the rate-limiting step in GSH biosynthesis

PMID 34665524

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Alcohol reward is increased after Roux-en-Y gastric bypass in dietary obese rats with differential effects following ghrelin antagonism

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Crescenz VA Medical Center in Philadelphia, and the University of Pennsylvania School of Medicine, tested a new and noninvasive way of delivering GSH through nasal sprays, and used proton magnetic resonance spectroscopy ( 1 H-MRS) to measure CNS uptake of GSH