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The SURPASS trials showed A1c reductions of 1.24% to 2.58% depending on the dose and comparator

A large 24-week trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo when combined with diet and exercise

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it can be started above 25 years age or as soon as signs of loss of elasticity and volume occur to slow down the aging process, preventing the need for more invasive or involved interventions later in life

The FDA has set the PDUFA action date for the BLA at March 28, 2026