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Retinal esr2 protein expression exhibited similar patterns in response to BPA as esr2a mRNA (Fig

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(5) Studies have shown that IGF-DES activates the IGF-1R with similar affinity to native IGF-1, triggering receptor autophosphorylation and activation of the PI3K/AKT and MAPK/ERK pathways

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It works by activating downstream biological processes such as: Receptor activation Growth factor upregulation Angiogenesis Cellular signaling cascades These processes continue for weeks after the peptide itself has been cleared from circulation