The LEADER (Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes) is the first trial to demonstrate positive outcomes in CVDs in patients with T2DM [34]
doi: 10.1016/j.clnu.2019.04.001
These medications work by mimicking the action of naturally occurring GLP-1, a hormone released from the gut after eating
Preclinical studies have shown that GLP-1RAs influence essential signaling pathways, including the activation of farnesoid X receptor (FXR) and liver X receptor (LXR), which are crucial in lipid metabolism and inflammation (Ibrahim et al., 2024
You may also start to notice improvement in blood sugar levels, as the medication boosts insulin secretion in response to meals and slows gastric emptying
Secondary hypertension is usually associated with an earlier age of onset, no family history, and a clear cause, such as renal or endocrine disorders, or iatrogenic triggers, such as the use of oral contraceptives (131)