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doi: 10.1073/pnas.89.18.8641
10.1007/s00244-009-9355-2 Arch
How it Works GLP-1 agonists mimic the actions of the naturally occurring GLP-1 incretin hormone, released in response to food intake
299,300 Phase 2 trials of once weekly administration of the amylin receptor agonist, eloralintide, in adults with overweight or obesity and without type 2 diabetes have demonstrated significant weight loss, with a mean decrease in body weight ranging from 916%, compared with 0.4% in the placebo group.301 Combination therapy of amylin and semaglutide has also shown promise in weight management, with over 40% of trial participants achieving a decrease in body weight of 25%
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