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Findings like those suggest a myeloproliferative or other hematologic disorder is producing the excess B12

Its original characterisation used isolated amphibian and reptilian skin bioassays before the cloned human receptors were available, and those historic potency data remain the reason the compound is described as superpotent in the older literature

The fear of potential long-term complications such as neuropathy, retinopathy, and kidney disease further exacerbates this stress, which frequently results in a clinically significant apprehension regarding complications [116, 117]

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Shaw PJ (2005) Molecular and cellular pathways of neurodegeneration in motor neurone disease

Patients mix these up constantly, so heres the short version