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So whats my opinion

Owing to intrinsic limitations of network meta-analysis, we avoided to analyze the effects of these drugs in several subgroupse.g., as stratified by age or the presence of CV disease or type 2 diabetesto avoid type 1 error due to the many subgroup analyses

Terrin G, Conte F, Oncel MY et al , Paracetamol for the treatment of patent ductus arteriosus in preterm neonates: a systematic review and meta-analysis

Nolte Kennedy MS (2012): Pancreatic Hormones & Antidiabetic Drugs (Chapter 41)

A pilot study has indicated that metformin may enhance feelings of satiety and decrease food-related anxiety in certain individuals with PWS, potentially through the mechanism of improved insulin sensitivity [39]

Compounded medications have not undergone the same rigorous testing for effectiveness and safety as FDA-approved drugs