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Constitutive activation of NRF2, mainly via loss-of-function mutations in the CUL3-adapter KEAP1 or gain-of-function mutations in NFE2L2 , is thought to provide a fitness advantage to tumor cells in confronting metabolic/oxidative stress resulting from dysregulated growth (DeNicola et al, 2011

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[PubMed | ClinicalTrials.gov | DOI] Wadden TA, Bailey TS, Billings LK, et al

Probiotics and their role in the management of type 2 diabetes mellitus (short-term versus long-term effect): a systematic review and meta-analysis

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