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However, a landmark July 2025 study published in the Proceedings of the National Academy of Sciences (PNAS) by Shankar, Davis, Bonilla, et al., revealed a fascinating and complex paradox regarding redox homeostasis in these conditions

Misclassification can lead to unnecessary avoidance recommendations for allergens that may not be clinically relevant or, conversely, missed diagnoses in cases where contact allergy is a true driver [6]

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[15] reported the enzymatic GSH production using metabolic engineered S

These disruptions lead to water and sodium influx, potassium efflux, cell swelling, membrane potential changes, and eventual cell lysis, which then releases intracellular contents, eliciting an inflammatory phenotype through DAMP release and triggering immune responses (Murao et al., 2021)