6c,d), increased sensitivity to DNA-damaging agents (Extended Data Fig
GSH binds toxins, heavy metals, and drug metabolites, thereby increasing their water solubility for excretion
Most published topical work uses 0.010.1% formulations
Dentally relevant examples (not by any means exhaustive): (3) Inducers CYP450 3A4: Phenytoin (epilepsy) Carbamazepine (epilepsy, trigeminal neuralgia) Rifampicin (TB) St Johns Wort (an over-the-counter supplement) Inhibitors CYP450 3A4: Grapefruit juice Clarithromycin (antibiotic) Erythromycin (antibiotic) Fluconazole (antifungal) Drugs metabolised by CYP450 3A4: Clarithromycin (antibiotic) Erythromycin (antibiotic) Warfarin (anticoagulant) Some statins e.g
8 To enhance bioavailability, Unilever R&D developed a glutathione amino acid precursor (GAP) blend to stimulate de novo glutathione synthesis
Carmeli C, Knyazeva MG, Cunod M, Do KQ