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Esta estimulacin de la secrecin de insulina por GLP-1 en la clula beta en humanos resulta de la capacidad de las incretinas en inhibir la actividad del canal de potasio ATP dependiente en presencia de glucosa, y aumento de influjo de calcio a travs de canales de calcio tipo L voltaje dependiente con aumento del calcio citoslico desde los depsitos intracelulares (14)

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While specific renal dose adjustments are not routinely required for GLP-1 receptor agonists or tirzepatide, patients should be monitored for dehydration and potential kidney injury, particularly when starting treatment

Between the pharmacological options, the GLP-1RA, originally approved for the treatment of DM2, have been demonstrated to be useful for body weight reduction in obese individuals

Why Are Medications Needed

Infusion of GLP-1 or saline was initiated simultaneously with the consumption of the breakfast test meal