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Rarely, meningeal melanocytes may undergo malignant transformation into meningeal melanocytosis and melanomatosis and diffusely disseminate throughout the meninges [18]

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This induced a shift from the pro-inflammatory M1 phenotype, as indicated by decreased expression of CD11b, iNOS, and IL-1, to the anti-inflammatory M2 phenotype, as indicated by increased levels of Arg-1 and TGF-1