[3] This chelation-and-delivery role is the mechanistic seed from which most downstream effects grow, and it is intrinsic to the molecule regardless of how it is administered
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To assess the utility of the model in a real world setting, we applied the model to a set of EHR data not used during model construction, and predicted efficacy at 6 months, assuming that the drug type and final dose was unknown at time point zero
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A randomized, open-label, crossover study to evaluate the pharmacokinetic profiles of rotigotine after a single dose of LY03003 (28 mg) versus after a week of daily NEUPRO transdermal patch (4 mg Every 24 h) in healthy volunteers (NCT04384666), (2020)
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