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YueSJLiuJWangWXWangATYangXYGuanHSet alBerberine treatment-emergent mild diarrhea associated with gut microbiota dysbiosis

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The increased cAMP levels in cardiac cells activate exchange protein directly activated by cAMP (EPAC) and protein kinase A (PKA), which regulate a multitude of downstream effectors involved in cardiac contractility, relaxation, and hypertrophy [14]

Women using oral contraceptives should use an additional contraceptive method for 4 weeks after starting treatment and after each dose increase

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CAFs-induced ECM remodeling results in increased tissue stiffness and the activation of mechanotransduction signaling pathways, such as integrin-FAK and YAP/TAZ signaling, thereby conferring increased malignancy to tumors (121)