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Pharmacological Reviews, 1998

and 6)ischemia resulting from transient four-vessel occlusion (reviewed in [45])

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After that, the lipid radical combine with O 2 to form a lipid peroxyl radical (LOO), which then interacts with adjacent PUFAs to form lipid hydroperoxide (LOOH), and many electrophilic species such as malondialdehyde (MDA), and 4-hydroxynonenal (4HNE) (Rice-Evans and Burdon, 1993