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Based on these studies, the treatment efficacy of GLP-1R agonists in patients with DPN is still controversial

The ratio of reduced GSH to the disulfide form (GSH/GSSG) within the endoplasmic reticulum ranges from 1:1 to 4:1, whereas the overall cellular GSH/GSSG ratio ranges from 30:1 to 100:1 (26) (Figure 2)

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