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GSH depletion was apparent after all three treatments (Fig

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ROS are produced in response to a variety of stimuli, such as ultraviolet radiation, cigarette smoke, alcohol, nonsteroidal anti-inflammatory drugs, and infections

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3.2 Amino acid metabolic reprogramming 3.2.1 The central role of the glutamate-GSH pathway in ferroptosis Ferroptosis is highly dependent on GPX4-mediated reduction of lipid peroxides, and reduced GSH serves as GPX4s substrate