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Medications to use cautiously: NSAIDs (ibuprofen, naproxen): While not contraindicated, NSAIDs carry gastrointestinal risks that may be compounded by semaglutide's GI effects

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Although VSMCs and the kidney play integral roles in BP regulation, there were no baseline differences in systolic, diastolic, or mean arterial pressure (MAP) between Glp1r VSM+/+ and Glp1r VSM/ mice, despite a marked reduction in kidney and renal artery Glp1r expression in Glp1r VSM/ mice (Figure 2, AC)

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Tirzepatide , on the other hand, targets two hormonesGLP-1 and GIP (glucose-dependent insulinotropic polypeptide)to enhance its effects

[DOI] [PMC free article] [PubMed] [Google Scholar] 178.Dudley J.T., Listgarten J., Stegle O., Brenner S.E., Parts L