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NAC replenishes and maintains hepatic GSH stores by providing cysteine, the substrate which detoxifies reactive metabolites of APAP.23,24,56,75 In addition, it may reduce NAPQI back to APAP by enhancing the sulfonation pathway of APAP metabolism.56,75 Administering NAC to patients with APAP overdose may reduce mortality from 5% to 0.7% of patients, and thus timely administration is critical.71 Table 2 lists commonly accepted indications for treatment with NAC in the setting of acute over-ingestion
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HCV subtyping with VERSANT HCV Genotype 2.0 line probe assay The line probe assay failed to correctly identify the HCV subtype in 15.2% of genotype 1, 27.3% of genotype 2, 7.7% of genotype 3, 52.9% of genotype 4 and 40% of genotype 6 cases (Table 3)
