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19 Twenty-eight families with clinical symptoms of severe PGK deficiency have been described, and in 20 of these families the causative mutation is known

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However, symptoms are far more likely to be related to underlying conditions that cause B12 elevationsuch as liver disease, kidney dysfunction, or haematological disordersrather than the elevated B12 itself

References Frias JP, Deenadayalan S, Erichsen L, et al

(2024) 15:e00772

The reality is more straightforward: Published phase 3 trials found that premenopausal women with HSDD who took bremelanotide had increased sexual desire and decreased distress about low sexual desire after 24 weeks, compared with those in placebo groups