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Here, specific enhancement of hepatic AKT S473 phosphorylation, but not T308, with CI/VI and increased protein and gene expression of Irs2 , but not Irs1 by cotadutide treatment supports this concept and complements previous observations 34,35,36

Beyond weight loss and glucose control, GLP-1 RAs were associated with improved insulin resistance and modest reductions in triglyceride levels, although low-density lipoprotein (LDL) cholesterol changed little across studies

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