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Altered B12 handling and reduced clearance in kidney disease, and both cellular release and reduced clearance in liver disease, can raise B12, so supportive renal or hepatic findings make those causes plausible

PGs are synthesized from free arachidonic acid via two isoforms of cyclooxygenase (COX, also referred to as PGH2 synthetase)

Nucleic Acids Res 51(3):10871102

Firstly, excessive iron intake is caused by multiple blood transfusions in TDT patients, which require blood transfusion therapy

doi: 10.1016/j.psyneuen.2022.105667, 21

How Programs Handle Safety and Side Effects Starting any new medication comes with questions about safety