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Recent finding in TBK1 deficiency mice suggested that loss of TBK1 in microglia causes an aging-like inflammatory state in these cells

Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice

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Unlike glutathione, humans cannot produce vitamin C (ascorbic acid) internally

Following chronic (6 week) feeding with an ethanol-containing liquid diet, the Gclm KO mice were unexpectedly found to be protected against steatosis despite showing increased oxidative stress (as reflected in elevated levels of CYP2E1 and protein carbonyls)